Volume 7, Issue 3, September 2019, Page: 88-93
Anabolic Steroids Effects on Bone Regeneration
José Carlos Pansieri, Institute of Biomedical Sciences, Department of Anatomy, Federal University of Alfenas, Alfenas, Brazil
Alessandra Esteves, Institute of Biomedical Sciences, Department of Anatomy, Federal University of Alfenas, Alfenas, Brazil
Wagner Costa Rossi Junior, Institute of Biomedical Sciences, Department of Anatomy, Federal University of Alfenas, Alfenas, Brazil
Received: Jun. 9, 2019;       Accepted: Jul. 16, 2019;       Published: Jul. 30, 2019
DOI: 10.11648/j.ajss.20190703.12      View  34      Downloads  14
Abstract
In recent decades, the importance given to body appearance has grown dramatically, as has the consumption of so-called "body image drugs," which include androgenic anabolic steroids (AAS), synthetic substances derived from testosterone. Although the therapeutic use of anabolic steroids are beneficial and necessary to body when there is reduction or depletion of these substances, the excessive use is related to negative interference in fracture healing process. Thus, the objective of study was to verify if there is influence of AAS in process of bone repair. For this, twenty Wistar rats were used, in which a fracture with bone loss was performed on left fibular diaphysis. Subsequently, they were divided into four groups and the animals were treated for one (1) month, with physiological solution (0.02 ml), Durateston® (83.3 mg / kg [0.02 ml]) and Deca Durabolin® (16.6 mg / kg [0.02 ml]), applied once a week. The results showed that there was a significant loss in bone healing on groups treated with AAS, since there was no regeneration in fractured fibula, besides increasing resorption process at the ends of fracture stumps. For this reason it is possible to conclude that the misuse of AAS interferes negatively in metabolism of bone tissue reinforcing the danger of indiscriminate use for health, warning that, addition other biological tissues, the bone may be affected by abuse of these substances.
Keywords
Anabolic Steroids, Testosterone, Fracture Fibula, Bone Regeneration
To cite this article
José Carlos Pansieri, Alessandra Esteves, Wagner Costa Rossi Junior, Anabolic Steroids Effects on Bone Regeneration, American Journal of Sports Science. Vol. 7, No. 3, 2019, pp. 88-93. doi: 10.11648/j.ajss.20190703.12
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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