Volume 7, Issue 2, June 2019, Page: 53-59
Resistance High-Intensity Interval Training (HIIT) Improves Acute Gluconeogenesis from Lactate in Mice
Gabrielle Yasmin Muller, Department of Physical Education, State University of Maringá, Maringá, Brazil
André Henrique Ernandes de Amo, Department of Biological Sciences, State University of Maringá, Maringá, Brazil
Karen Saar Vedovelli, Specialization in Human Physiology, State University of Maringá, Maringá, Brazil
Isabela Ramos Mariano, Program of Graduate Studies in Physiological Sciences, State University of Maringá, Maringá, Brazil
Giselle Cristina Bueno, Program of Graduate Studies in Physical Education, State University of Maringá, Maringá, Brazil
Julia Pedrosa Furlan, Program of Graduate Studies in Physiological Sciences, State University of Maringá, Maringá, Brazil
Maria Montserrat Diaz Pedrosa, Department of Physiological Sciences, State University of Maringá, Maringá, Brazil
Received: Apr. 12, 2019;       Accepted: May 23, 2019;       Published: Jun. 4, 2019
DOI: 10.11648/j.ajss.20190702.12      View  446      Downloads  80
High-intensity interval training (HIIT) markedly activates muscle anaerobic glycolysis and increases blood lactate. As the liver is a major organ for lactate clearance from the bloodstream, it might improve gluconeogenesis from lactate (NEO-lac) after a period of resistance HIIT. NEO-lac was evaluated by in situ liver perfusion in mice subjected to a resistance HIIT for 4 (T4) or 8 (T8) weeks, or not trained (T0). Perfusion was carried out immediately after an incremental exercise session to test the acute NEO-lac. Muscle strength (expressed as relative maximum load) and blood lactate were higher in T4 than in T0, but NEO-lac did not differ, possibly because of energy discharge of the liver and substrate overload. After 8 weeks of HIIT (T8), both muscle strength and liver NEO-lac increased, but blood lactate did not. The resistance HIIT for 8 weeks modulated liver gluconeogenic efficiency and capacity, which are important mechanisms for the improved clearance of blood lactate.
Lactate, Resistance HIIT, Mouse, Liver, Performance
To cite this article
Gabrielle Yasmin Muller, André Henrique Ernandes de Amo, Karen Saar Vedovelli, Isabela Ramos Mariano, Giselle Cristina Bueno, Julia Pedrosa Furlan, Maria Montserrat Diaz Pedrosa, Resistance High-Intensity Interval Training (HIIT) Improves Acute Gluconeogenesis from Lactate in Mice, American Journal of Sports Science. Vol. 7, No. 2, 2019, pp. 53-59. doi: 10.11648/j.ajss.20190702.12
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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